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The 4 Alkaloids that we are now testing for in Kratom which will be posted on this website in the beginning of 2020 are as follows:
Mitragynine: Indole alkaloid. Analgesic, antitussive, antidiarrheal, adrenergic, antimalarial, (5-HT2A) antagonist. Mitragynine is the primary alkaloid in kratom, and is believed to be responsible for the majority of its effects. Roughly 66% of total alkaloid content found in Kratom leaf.
Paynantheine: Indole alkaloid. Appears to be a smooth muscle relaxer, but there is limited research available and more needs to be done. 8.6% to 9% of total alkaloid contents in Kratom leaf. Second most abundant alkaloid.
Speciogynine: Diastereomer of mitragynine. Possible smooth muscle relaxer. 6.6% to 7% of total alkaloid contents of kratom leaf, representing the third most abundant alkaloid.
7-hydroxymitragynine: Analgesic and potent mu-opioid agonist, antitussive, and antidiarrheal. Along with mitragynine, 7-hydroxymitragynine is responsible for the primary effects of Kratom. It represents roughly 2% of total alkaloid content found in Kratom leaf, though this is highly variable. Some leaves have undetectable levels.